FBS Xtra
Controlled. Defined. Reduced.
Fetal Bovine Serum (FBS) has been an established additive in cell culture media for decades. Its unique growth-promoting properties make it a valuable and indispensable ingredient for mammalian cell culture. All over the world, researchers and biopharmaceutical manufacturers depend on a regular and consistent supply of serum.
Until now, they are often at mercy of the market's difficulties in availability and fluctuant pricing. To target these issues, we have developed – in cooperation with the University of Frankfurt – a new product to lead the way into a more defined culture environment: FBS Xtra.
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What is FBS Xtra?
Reduced serum content
FBS Xtra contains a significantly reduced amount of FBS and is supplemented with highly pure and defined components.
Batch-to-batch homogeneity
With identified key components responsible for a successful and controlled cell growth, we can keep batch-to-batch variations of FBS Xtra to a minimum.
Significantly reduced cell stress
Using FBS Xtra, the levels of phosphorylated p38 are significantly reduced, when compared to standard FBS.
Key Components That Make the Difference
FBS Xtra combines high-quality FBS with growth-promoting factors such as insulin, transferrin, trace elements, and amino acids in a chemically-defined and recombinant form.
Through supplementation of these highly pure and defined components, it is possible to significantly reduce the amount of fetal bovine serum in FBS Xtra.
Your Advantages at a Glance
Our team at Capricorn Scientific has developed an alternative to traditional FBS in collaboration with the University of Applied Science Frankfurt am Main.
FBS Xtra is produced with key components responsible for successful and controlled cell growth and a reduced serum concentration. This creates more defined growth conditions while keeping batch-to-batch variations to a minimum.
- High performance with consistent quality
- Reduced cell-stress
- Batch-to-batch homogeneity
- Reduced serum content
- Chemically-defined composition of trace elements, amino acids, vitamins, and cofactors
Validated for Diverse Cell Lines
Extensive performance tests with several widely used cell lines showed that FBS Xtra achieved even better results than standard FBS for many cell types. FBS Xtra preserves regular cell morphology while leading to a better viability of your cells and reducing cellular stress!
- HeLa
- NIH-3T3
- HEK293
- Jurkat
- CHO
- Vero
- L929
- ...and many more
VIABILITY ASSAY
The viability of different cell lines, cultured with FBS Xtra in reference to standard FBS, showed comparable or even better results.
CELL-STRESS ASSAY
The p38 MAP kinase gets initiated by a variety of cellular stresses. It is activated by phosphorylation to help the cells adapt and cope with noxious conditions. High levels of phosphorylated p38 signify a more stressful environment.
Two weeks after cultivation of HEK293 cells, supplemented with 10% standard FBS versus 10% FBS Xtra, phosphorylated p38 was measured as a percentage of the total amount of p38.
For FBS Xtra, reduced levels of p38 phosphorylation were observed, when compared to standard culture conditions.
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FBS Xtra, Fetal Bovine Serum (FBS), Collected in South America
FBS Xtra, Fetal Bovine Serum (FBS), Collected in South America
